Informatics Publishing Limited

G. Sarathkumar ¹, R. Sambathkumar ¹, K. Sumathi ²

Affiliations
1 Department of ECE, Dr. Mahalingam College of Engineering and Technology, Pollachi, IN
2 Department of ECE, Dr. Mahalingam College of Engineering and Technology, Pollachi, IN

Abstract

The wireless mobile network is particularly vulnerable due to its features of open medium, dynamic changing topology, cooperative algorithms, lack of centralized monitoring and management point, and lack of a clear line of defense. The traditional way of protecting mobile networks with firewalls and encryption software is no longer sufficient and effective. New distributed intrusion detection schemes must be designed for wireless mesh mobile networks. In the first phase of the work a static simulation was completed for analyzing load balancing approaches in mobile network. In the second phase of the work we try to devise a method where we put a distributed IDS agent in each node of the wireless mobile network so that each node studies the packet flow in the corresponding mobile network and distributes it to the near by nodes in the mobile network. With this, the nodes will know the details of the packet flow in the entire mobile network using the swarm intelligence technique; thereby it tries to identify the intrusion that happens by various rule mining techniques. Here we implement hierarchical, extensible and flexible detection architecture to thwart such threats. Thus this system will help us detecting and tracking the intrusion at the early level itself with the use of hierarchical model. This will help us to reduce the false positives as well as false negatives, which will give more accuracy in detection and also increasing the quality of service in the mobile network. The overall load balancing characteristic of the network is hence improved.

Keywords

Pheromone, Intrusion, Anomaly Detection, Immune System.

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R. B. Saudagar ¹, R. Sambathkumar ², R. S. Bachhav ²

Affiliations
1 KCT’S R.G. Sapkal College of Pharmacy, Anjaneri, Nashik 422 213, IN
2 JKK Nataraja College of Pharmacy, Komarapalyam, Namakal, TN, IN

Abstract

Trichopus zeylanicus Gaertn is a perennial herb belongs to the family Trichopodaceae popularly known as "Arogyapacha" or 'Arokyapachilai" in Malayalam literally meaning "the green that gives strength". A critical survey of the Ayurveda classics, suggests that the 'Arogyappacha' may be the divine 'Varahi'described by Sushruta. Geographically the plant is available in Agasthyar hills in the Western Ghats, Kerala, Singapore, Sri Lanka, Thailand and the Southwestern Ghats Mountains of South India. The herb grows on sandy soil near rivers and stream in shady places in low land and intermediate altitude forests. Various ancient Ayurveda classics, the authors have come across with some descriptions of a plant which matched strikingly with 'Arogyappacha' Sushruta, while dealing with the various divine drugs along with 'Some' also described one 'Varahi' - which he described as 'Kandha sambhava' -rhizomatous, 'Ekapatra' single leaves arising from a stem and 'Anjana samaprabha' - shining like he grey-black stone. Ethnopharmacological studies claimed that, the oral LD50 were found to be more than 3000mg/kg, with no signs of abnormalities or any mortality observed for 15 days period. Seeds of Trichopus zeylanicus showed a potent adaptogenic or antistress properties against a variety of stresses in both rats and mice. Treatment with Trichopus zeylanicus protected mice from tumour cell growth. Trichopus zeylanicus extract has been evaluated for its antihepatotoxic and cholerectic activities in rats. The effects of Trichopus zeylanicus on reactive oxygen species induced plasmid DNA (pBR322) cleavage were also investigated. Trichopus zeylanicus contains NADH, polyphenols and sulfhydryl compounds, which have the ability to scavenge reactive oxygen species.

Keywords

Trichopus zeylanicus, Adaptogenic, Analgesic, Arogyapacha.

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M. Vijayabaskaran ¹, G. Babu ¹, N. Venkateswaramurthy ¹, P. Sivakumar ¹, P. Perumal ¹, T. Sivakumar ², R. Sambathkumar ³, B. Jayakar ⁴

Affiliations
1 JKK Nataraja College of Pharmacy, Komarapalayam, Namakkal District, Tamil Nadu 638183, IN
2 Nandha College of Pharmacy, Erode, Tamil Nadu 638 052, IN
3 Department of Pharmaceutics, Seventh of April University, Al-Zawia City, LY
4 Vinayaka Missions College of Pharmacy, Salem, Tamil Nadu, IN

Abstract

The study was aimed at evaluating the antitumor and antioxidant activities of ethanol extract of Pseudarthria viscida (Family: Fabaceae) against Ehrlich ascites carcinoma (EAC)-bearing Swiss albino mice. The ethanol extract of Pseudarthria viscida (EEPV) was administered at the doses of 100 and 200 mg/kg in mice for 14 days after 24 h of tumor inoculation. The effect of EEPV on the growth of transplantable murine tumor, life span of EAC bearing mice, hematological profile and liver biochemical parameters were estimated. Treatment with EEPV decreased the tumor volume and viable cell count thereby increasing the life span of EAC bearing mice and brought back the hematological parameter more or less normal level. The effect of EEPV decreases the level of lipid peroxidation and protein content and significantly increased the level of antioxidant enzymes such as Catalase (CAT), Glutathione (GSH) and Superoxide dismutase (SOD). These observations are suggestive of the protective effect of EEPV against Ehrlich Ascites Carcinoma (EAC).

Keywords

Pseudarthria viscida, Ehrlich Ascites Carcinoma, Hematological Parameter, Antioxidant, Antitumor Activity.

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S. Gomathi ¹, R. Shanmuga Sundaram ², M. Vijayabaskaran ¹, C. Kannan ³, R. Sambathkumar ³

Affiliations
1 Department of Pharmaceutical Chemistry, JKK Nattraja College of Pharmacy, Komarapalayam, Namakkal (Dist), Tamil Nadu - 638183, IN
2 Department of Pharmacology, JKK Nattraja College of Pharmacy, Komarapalayam, Namakkal (Dist), Tamil Nadu - 638183, IN
3 Department of Pharmaceutics, JKK Nattraja College of Pharmacy, Komarapalayam, Namakkal (Dist), Tamil Nadu - 638183, IN

Abstract

Background: Studies of antioxidant substances in foods and natural products have gained increasing interest. The prevalence of neurodegenerative diseases are increasing globally. Effective treatment is necessary to minimize the neuronal damage and oxidative stress. Traditional medicines offer potent pharmacological activity with minimal side effects compared to synthetic drugs to treat such chronic disorders. Objective: The present study was aimed to evaluate the neuroprotective effect of ethanol extract of Pedalium murex Linn. (EEPM) leaves against lipopolysaccharide (LPS)-induced endotoxemia. Materials and Methods: Neurodegeneration was induced in rats with a single intraperitoneal injection of LPS (1 mg/kg). The neuroprotective activity was investigated following LPS-induced endotoxemia and then subjecting the animals to a battery of behavioural tests such as open field test (OFT), elevated plus-maze (EPM) and forced swim test (FST) to test anxiety and depression. At the end of the study, rats were sacrificed, brain hippocampal region was isolated and biochemical parameters were analysed. Results: These results highlight the neuroprotective potential of EEPM in LPS-induced anxiety and depressive illness model which may be partially due to inhibition of oxidative stress-neuroinflammatory cascade. Conclusion: The present study proved that EEPM has promising anti-anxiety, antidepressant action and can be potential candidates for the management of LPS-induced neurodegeneration.

Keywords

Anxiety, Depression, Lipopolysaccharide, Oxidative Stress, Neuroprotection.

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